Why This Webinar?

In order to achieve the desired therapeutic effect, a drug must engage with its intended target. However, it's well known that the challenges associated with measuring target engagement (TE) in situ complicate preclinical development and are considered key factors in the high rate of attrition in clinical trials.

The cellular thermal shift assay (CETSA) is expected to ease these challenges, by facilitating direct measurement of intracellular TE at all stages of drug development. Since its invention in 2013, the CETSA® method platform has gained growing acceptance by many researchers working in Drug Discovery. It has proved its value in all areas from early target validation, through lead generation and optimisation to preclinical development and beyond.

The Speaker Panel

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Joseph Shaw
Senior Research Scientist, Discovery Biology
AstraZeneca

Teemu P. Miettinen, PhD
Cell Biologist
Massachusetts Institute of Technology (MIT)

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Nayana Prabhu
Research Fellow
Nanyang Technological University

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Daniel Martinez Molina
Chief Scientific Officer, Co-Founder
Pelago Bioscience

SAVE YOUR SPOT

Is Your Compound Actually Therapeutic?

How CETSA® is transforming Target Engagement in Drug Discovery

Thursday, March 22 at 12pm EDT | 4pm GMT

A COMPLIMENTARY WEBINAR ON

The CSO of Pelago Bioscience will briefly introduce the basics of the method platform.

Thereafter, leading researchers from AstraZaneca, MIT and Nanyang Technological University will present three different application examples:

CETSA HT screening on the Androgen receptor in a high throughput format

Thermal Proteome Profiling of palbociclib (Ibrance) and biomarker discovery using CETSA MS

CETSA MS phenotypic deconvolution and validation of mode of action of a small molecule with potential anti-cancer efficacy

Each case study will demonstrate the versatile applicability of CETSA in the Drug Discovery value chain. Following the case study presentations, there will be a short panel discussion and Q&A session with the audience.

In this 60-minute Webinar